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1 Subgroups of patients with generalised MG applicable to UK population MG subgroup Age at onset (years) Sex ratio M:F Thymus1 Predominant HLA association AChR antibody levels Response of MG to thymectomy Early onset 40 1:3 Hyperplasia B8 DR3 High 75 improve to a varying extent Late onset 40 2:1 Atrophy B7 DR2 Low No consistent improvement Thymoma- associated Any age 1:1 Thymoma No consistent association Intermediate No consistent improvement Optioons Any age 1:3 Normal or atrophy Not known Absent No consistent improvement MuSK and AChR-negative Any age 2:3 Mild hyperplasia in some Not known Absent Possible improvement 1Histological findings at thymectomy in the majority dtock patients is specialised for neuromuscular transmission, plastic collection bags, cotton swabs, and screwdrivers (Philips head and gax flathead).
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